Spegra (Dolutegravir, Emtricitabine and Tenofovir Alafenamide) x 30 Tablets

Benefits of Dolutegravir / Emtricitabine / Tenofovir Alafenamide

• Strong combination therapy for effective HIV control.
• Helps reduce viral load to undetectable levels.
• Increases and maintains CD4 (immune) cell counts.
• Reduces the risk of HIV-related infections.
• Once-daily convenient oral tablet.
• High barrier to drug resistance (especially dolutegravir).
• Supports long-term viral suppression.
• Improves immune system function.
• Helps improve quality of life with consistent use.
• Well-established and widely used first-line HIV regimen.

How Does It Work?

This combination works by blocking HIV at different stages of its life cycle. Dolutegravir inhibits the integrase enzyme, preventing viral DNA from integrating into human cells. Emtricitabine and Tenofovir Alafenamide are nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs) that block reverse transcriptase, stopping the virus from making copies of its genetic material. Together, they reduce viral replication and help control HIV infection.

Precautions

• Take the medicine exactly as prescribed by your doctor.
• Do not stop treatment without medical advice.
• Regular blood tests may be required to monitor kidney and liver function.
• Inform your doctor if you have hepatitis B infection (stopping treatment suddenly may worsen it).
• Inform your doctor about all medicines, supplements, and herbal products you take.
• Take antacids, calcium, or iron supplements only as advised (may affect absorption of dolutegravir).
• Use effective contraception during treatment if advised.
• Use during pregnancy or breastfeeding only under medical supervision.
• Take the tablet at the same time each day.
• Practice safe measures to prevent HIV transmission.

Side Effects

• Headache and dizziness
• Nausea or diarrhea
• Trouble sleeping (insomnia)
• Fatigue or weakness
• Weight gain or changes in cholesterol levels

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